Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora

Ana González-Hernández,Jimmy Borloo, Iris Peelaers,Stijn Casaert,Georges Leclercq,Edwin Claerebout,Peter Geldhof

International Journal for Parasitology（2018）

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摘要

•Protective capacities and immune responses of a native and recombinant vaccine against Cooperia oncophora were evaluated.•Protection is correlated with increased systemic and local antigen-specific memory CD4-T cells.•Protection is correlated with the production of antibodies with increased specificity.

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关键词

Activation-associated secreted proteins,Recombinant vaccine,Helminths,Cooperia oncophora,Immune response

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