Calcitonin induces collagen synthesis and osteoblastic differentiation in human periodontal ligament fibroblasts.

•CT is significantly higher expressed in the gingival crevicular fluid of patients with periodontitis.•CT level is association with the occurrence and development of periodontitis.•CT upregulates collagen expression through TGF-β1 mediated pathway in hPDLFs.•CT induces osteoblastic differentiation of hPDLFs through BMP-2/4 mediated pathway in hPDLFs.