Dose-dependent effect of donepezil administration on long-term enhancement of visually evoked potentials and cholinergic receptor overexpression in rat visual cortex.

Mira Chamoun,Marianne Groleau,Menakshi Bhat,Elvire Vaucher

Journal of Physiology-Paris（2016）

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摘要

•The cholinergic potentiation of visual training enhances long-term responses in V1.•The cholinergic potentiation of visual training triggers AChR subtypes upregulation.•A high dose of donepezil elicits stronger and broader effects than a low dose.•Donepezil use could be implemented to visual rehabilitation in human.

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关键词

Cholinergic enhancement,Acetylcholinesterase inhibitors,Cortical activity,Muscarinic receptors,Nicotinic receptors,Visual cortex

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