Influence of Obesity on the Course of Malignant Neoplastic Disease in Patients After Pulmonary Metastasectomy.

Background/Aim: The aim of the study was to determine whether increased body mass index (BMI) in patients operated on for lung metastases influences the course of the disease. Materials and Methods: The retrospective data of 97 patients previously operated on for different malignancies were analyzed. There were 40 obese patients (BMI > 30 kg/m(2), mean 33.9 +/- 4.5) and 57 non-obese patients (BMI 25.8 +/- 2.7 kg/m(2), p< 0.001). Disease-free interval (DFI), the overall survival (OS) and survival after pulmonary metastasectomy were analyzed. Results: DFI and OS were longer in obese than in non-obese patients (82.1 +/- 83.5 months vs. 43.0 +/- 44.4, p< 0.01 and 110.7 +/- 81.3 months vs. 69.9 +/- 52.9 p< 0.005, respectively). Survival after pulmonary metastasectomy was 27.2 +/- 25.6 months and was longer in obese and overweight patients than in normal weight patients (20.2 +/- 18.4 months vs. 29.4 +/- 26.5, p< 0.05). Conclusion: Being obese or overweight is a favorable prognostic factor in patients after surgical resection of lung metastases of different malignancies.