A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine

Valeria Pecoraro,Lara Maria Sardone,Mariangela Chisari,Flora Licata,Guido Li Volsi,Vincenzo Perciavalle,Lucia Ciranna,Lara Costa

Neuroscience（2017）

引用 10|浏览16

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摘要

•High-affinity PAC1 receptors induce ACh-mediated effects in the hippocampus.•PAC1 receptors pre-synaptically modulate glutamatergic synaptic transmission through ACh.•PACAP at very low doses might be beneficial in cognitive diseases with reduced cholinergic transmission.

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关键词

ACh,ACSF,AMPA,CA1,CA3,cAMP,D-AP5,EPSC,EPSCAMPA,fEPSPs,LTD,LTP,mEPSCs,NMDA,PACAP,PPF,TTX

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