Immunomodulatory Device Therapy in a Pediatric Patient With Acute Kidney Injury and Multiorgan Dysfunction.

Acute kidney injury (AKI) that requires continuous renal replacement therapy (CRRT) is a significant complication in critically ill patients with mortality rates approaching 50%. Although children are generally healthy, the development of AKI that requires CRRT in intensive care unit (ICU) pediatric patients results in a similarly high mortality rate.1–3 AKI results in a systemic inflammatory response syndrome with the activation of circulating leukocytes, predominantly neutrophils and monocytes, which contribute to patient morbidity and mortality in multiorgan failure.