dNK derived IFN-γ mediates VSMC migration and apoptosis via the induction of LncRNA MEG3: A role in uterovascular transformation.

Weifang Liu,Xiaoxia Liu,Minglian Luo,Xiaoping Liu,Qingqing Luo,Hui Tao,Di Wu,Sisi Lu,Jing Jin,Yin Zhao,Li Zou

Placenta（2017）

引用 44|浏览27

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摘要

•dNK/IFN-γ treatment led to up-regulation of MEG3 expression in VSMCs.•MEG3 over-expression and dNK/IFN-γ treatment inhibited VSMC proliferation.•Both MEG3 and dNK/IFN-γ encouraged VSMC apoptosis and migration.•Both MEG3 and dNK/IFN-γ promoted p53 and MMP-2 expression in VSMCs.

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关键词

LncRNA MEG3,VSMC loss,Spiral artery remodeling,dNK,IFN-γ

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