Krüppel-like factor 4 regulates amyloid-β (Aβ)-induced neuroinflammation in Alzheimer's disease.

Liuhong Li,Xiaohong Zi,Deren Hou,Qiuyun Tu

Neuroscience Letters（2017）

引用 19|浏览4

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摘要

•Oligomeric Aβ42 increases the Klf4 expression in microglial BV2 cells.•Gene and protein expressions of Klf4 are increased in brain microglia of AD mice.•p53 mediates Aβ42-induced expression of Klf4.•Silence of Klf4 restores Aβ42-induced neuroinflammation.•Overexpression of Klf4 exacerbates Aβ42-induced neuroinflammation.

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关键词

AD,Aβ,Klf 4,TNF-α,IL-1β,iNOS,COX-2,CNS,LPS,HFIP,PBS,DMEM,NaHCO3,SDS-PAGE,PVDF,HRP,PCR,PFA

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