Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model.

Gary N Y Chan,Rebecca A Evans,David B Banks,Emily V Mesev,David S Miller,Ronald E Cannon

Neuroscience Letters（2017）

引用 26|浏览26

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摘要

•Characterization of drug efflux transporters at the blood-brain and blood-spinal cord barriers in an ALS SOD1 rat model.•P-glycoprotein transport activity and expression levels were increased at the CNS barriers in rats at the ALS symptomatic stage.•P-glycoprotein induction can restrict CNS delivery of current and new ALS pharmacotherapies that are substrates for this transporter.

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关键词

ABC,ALS,BBB,BCRP,BSCB,CNS,MRP2,P-gp,SOD1

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