Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE(2017)
Abstract
Personalized and precise nanomedicines are highly demanded for today's medical needs. Liposomes are ideal candidates for the construction of multifunctional drug delivery systems. In this study, a liposome was used to improve the clinical issues of docetaxel (Doc), a potent antimitotic chemotherapy for prostate cancer (PC). RLT, a low-density lipoprotein receptor (LDLR)-binding peptide, and PEG were conjugated to the liposomes, and gold nanorods (GNRs) were also incorporated into the liposomes. The GNRs/Doc-liposome-RLT (GNRs/DocL-R) was tested in PC-3 cells and in PC-3 tumor-bearing nude mice. Results showed that GNRs/DocL-R possessed a diameter approximately 163.15 +/- 1.83 nm and a zeta potential approximately -32.8 +/- 2.16 mV. GNRs/DocL-R showed enhanced intracellular entrance, increased accumulation in the implanted tumor region, and the highest tumor inhibition in vitro and in vivo. Therefore, the multifunctional GNRs/DocL-R was a potential cancer treatment via combined chemo -and thermotherapy.
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Key words
gold nanorods,docetaxel,liposomes,prostate cancer,LDL receptor targeting
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