Effectiveness of low-dose radiation for primary cutaneous anaplastic large cell lymphoma.

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is conventionally treated with radiation therapy (RT) doses ≥30 Gy. In a series of 21 patients with pcALCL, responses were examined after a range of RT doses: ≤20 Gy, 20 to 29 Gy, and ≥30 Gy. Three-year freedom from local relapse was 100%, 86%, and 100%, respectively (P = .28). Low-dose RT appeared to be an acceptable approach for local control in the setting of the indolent, chronic course of pcALCL in this series.