Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription

•Didox suppresses FcεRI-mediated mast cell degranulation and cytokine production.•Didox increases antioxidant production and reduces oxidative stress.•Didox inhibits NFκB and AP-1 transcriptional activation.•Didox suppresses IgE-induced passive systemic anaphylaxis in vivo.