Up-regulation of BSEP and MRP2 by Calculus Bovis administration in 17α-ethynylestradiol-induced cholestasis: Involvement of PI3K/Akt signaling pathway.

Tao Wu,Qianrui Zhang,Jingjing Li, Hong Chen,Ji Wu,Hongping Song

Journal of Ethnopharmacology（2016）

引用 18|浏览2

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摘要

Calculus Bovis administration can alleviate liver injury and up-regulate the expression of BSEP and MRP2 in 17α-ethynylestradiol-induced cholestasis by a mechanism that may involve inhibiting the activated PI3K/Akt signaling pathway.

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关键词

ALT,ALP,GGT,TBIL,CB,EE,BSEP,MRP2,MRP4,CK19,PI3K,Akt,pAkt,GSH,BCRP

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