Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.

Mohamad El-Zaatari,Adam J Bass,Reanne Bowlby,Min Zhang,Li-Jyun Syu,Yitian Yang,Helmut Grasberger,Andrew Shreiner,Bei Tan,Shrinivas Bishu,Wai K Leung,Andrea Todisco,Nobuhiko Kamada,Marilia Cascalho,Andrzej A Dlugosz,John Y Kao

Gastroenterology（2018）

引用 26|浏览14

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摘要

IDO1 mediates gastric metaplasia by regulating the B-cell compartment. This process appears to be associated with type II hypersensitivity/autoimmunity. The role of autoimmunity in the progression of pseudopyloric metaplasia warrants further investigation.

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关键词

Kynurenine,Gastritis,SPEM,Humoral Immunity

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