Elevated Pre-Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection.
CLINICAL INFECTIOUS DISEASES（2017）
Abstract
Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39(+)CD8(+) T cell frequency was independently associated with mortality within 6 months of ART initiation.
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Key words
HIV,tuberculosis,early mortality,CD39,CD8(+) T cells
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