Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor.

Huifeng Niu,Hyunjin Shin,Feng Gao,Jacob Zhang,Brittany Bahamon,Hadi Danaee,Bohuslav Melichar,Russell J Schilder,Robert L Coleman,Gerald Falchook, Antoine Adenis,Kian Behbakht,Angela DeMichele,Elizabeth Claire Dees,Kimberly Perez,Ursula Matulonis,Piotr Sawrycki,Dirk Huebner,Jeffrey Ecsedy

EBioMedicine（2017）

引用 17|浏览33

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摘要

•Aurora A contains two single nucleotide polymorphisms (SNPs) at codons 31 and 57 that lead to functional amino acid changes•We evaluated the potential prognostic and predictive value of these SNPs and revealed the SNP at codon 57 may predict disease outcome and response to Alisertib in patients with solid tumors

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关键词

Aurora A kinase inhibitor,Alisertib,SNP,Prognosis,Predictive biomarker,Correlative analysis

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