Vascular protective effects of KLF2 on Aβ-induced toxicity: Implications for Alzheimer's disease.

Xuejun Fang,Xiaoli Zhong,Gang Yu,Si Shao,Qidong Yang

Brain Research（2017）

引用 17|浏览3

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摘要

•KLF2 expression decreased at both RNA and protein levels in the brain of AD cases.•Aβ treatment reduced the expression of KLF2.•Overexpressing KLF2 attenuated Aβ induced cytotoxicity.•Inhibition of KLF2 promoted Aβ1-42 induced cytotoxicity.

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关键词

Alzheimer’s disease,Amyloid beta,Kruppel like factor 2,Apoptosis

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