Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST).

Ryan H Takahashi,Cyrus Khojasteh,Matthew Wright,Cornelis E C A Hop,Shuguang Ma

Drug metabolism letters（2017）

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摘要

Quantitative assessment of metabolite coverage in safety species can be made using mixed matrix method with similar accuracy and scientific rigor to those obtained from validated bioanalytical methods. Moving forward, we are encouraging the industry and regulators to consider accepting the mixed matrix method for assessing metabolite exposure comparisons between humans and animal species used in toxicology studies.

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关键词

MIST,bioanalytical methods.,metabolite exposure,metabolite quantitation,metabolite-in-safety testing,mixed matrix method

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