Failure of daptomycin β-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium.

Vidthiya Menon,Rebecca Davis,Nick Shackel,Bjorn A Espedido,Alicia G Beukers,Slade O Jensen,Sebastiaan J van Hal

Diagnostic Microbiology and Infectious Disease（2018）

Cited 8|Views5

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Abstract

Daptomycin β-Lactam combination therapy offers “protection” against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation.

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Key words

Enterococcus faecium,VRE,Combination therapy,Daptomycin,Antibiotic resistance,Whole-genome sequencing

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