Cytokine-Induced Memory-Like Differentiation Enhances Unlicensed Natural Killer Cell Antileukemia and FcγRIIIa-Triggered Responses.

•Cytokine-induced memory-like NK cell differentiation enhances NK cell responses.•Memory-like differentiation augments licensed and unlicensed NK cell function.•Unlicensed NK cell antitumor responses are restored via memory-like differentiation.•FcγRIIIa stimulates enhanced IFN-γ production and killing by memory-like NK cells.•Mechanisms of memory-like functionality are distinct from human cytomegalovirus–adapted NK cells.