Phosphatidylcholine As A Metabolic Cue For Determining B Cell Fate And Function

Robert Barrington,Viktoriya Solodushko,Ileana Aragon,Joseph Brewer

JOURNAL OF IMMUNOLOGY（2014）

引用 13|浏览6

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摘要

•CCTα is required for antigen-specific, germinal center-derived antibody-secreting cells.•CCTα is required for antigen-specific, germinal center-derived memory B cells.•Phosphatidylcholine is required for germinal center B cell responses.

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关键词

CCTα,Antibody-secreting cell,Antibody,Germinal centers,T cell-dependent antigen,Unfolded protein response,Phospholipid biosynthesis

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