Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.
Wellcome open research(2016)
摘要
These findings provide a novel mechanistic explanation for mycobacterial intracellular persistence, and suggest that targeting interactions between the mycobacteria and host cell pathways may provide a novel avenue for development of anti-TB therapies.
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关键词
Lysosomal Calcium,Lysosomal Storage Diseases,Niemann-Pick Disease Type C,Tuberculosis
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