Kctd13 deletion reduces synaptic transmission via increased RhoA

Christine Ochoa Escamilla,Irina Filonova,Angela K. Walker,Zhong X. Xuan,Roopashri Holehonnur,Felipe Espinosa,Shunan Liu,Summer B. Thyme, Isabel A. López-García, Dorian B. Mendoza,Noriyoshi Usui,Jacob Ellegood,Amelia J. Eisch,Genevieve Konopka,Jason P. Lerch,Alexander F. Schier,Haley E. Speed,Craig M. Powell

NATURE（2017）

引用 144|浏览32

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摘要

Experimental evidence that global Kctd13 reduction leads to increased RhoA levels that reduce synaptic transmission, implicating RhoA as a potential therapeutic target for neuropsychiatric disorders associated with copy-number variants that include KCTD13 .

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关键词

Autism spectrum disorders,Cellular neuroscience,Molecular neuroscience,Synaptic transmission,Science,Humanities and Social Sciences,multidisciplinary

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