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Computational Correction of Copy-Number Effect Improves Specificity of CRISPR-Cas9 Essentiality Screens in Cancer Cells

Robin M Meyers,Jordan G Bryan,James M McFarland,Barbara A Weir,Ann E Sizemore,Han Xu,Neekesh V Dharia,Phillip G Montgomery,Glenn S Cowley,Sasha Pantel,Amy Goodale,Yenarae Lee,Levi D Ali,Guozhi Jiang,Rakela Lubonja,William F Harrington,Matthew Strickland,Ting Wu,Derek C Hawes,Victor A Zhivich,Meghan R Wyatt,Zohra Kalani, Jaime J Chang,Michael Okamoto,Kimberly Stegmaier,Todd R Golub,Jesse S Boehm,Francisca Vazquez,David E Root,William C Hahn,Aviad Tsherniak

Nature Genetics（2017）

Cited 1320|Views0
Key words
Cancer,Data processing,Functional genomics,Genome informatics,Software,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics
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