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Timing of valproic acid in acute lung injury: prevention is the best therapy?

George Kasotakis,Manuel D Galvan,Paw Osathanugrah, Neerav Dharia, Lauren Bufe, Zachary Breed,Joseph P Mizgerd,Daniel G Remick

Journal of Surgical Research（2017）

Cited 9|Views5
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Abstract
A narrow therapeutic window exists in this murine model of gram-negative pneumonia-induced acute lung injury and likely explains the lack of response in studies with late administration of anti-inflammatory therapies in clinical studies.
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Key words
Acute lung injury,Acute respiratory distress syndrome,Histone deacetylase inhibitors,Valproic acid,Timing of administration,Therapeutic window
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