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The role of TGFβ receptor 1-smad3 signaling in regulating the osteoclastic mode affected by fluoride.

Haolan Yu,Ningning Jiang,XiuHua Yu,Zhitao Zhao,Xiuyun Zhang,Hui Xu

Toxicology（2018）

Cited 22|Views9
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Abstract
•Fluoride upregulated 303 miRNAs expression and downregulated 61 miRNAs.•Fluoride exhibited biphasic effect on osteoclast viability, formation and function.•Fluoride indicated little effect on expression of RANK protein.•SB431542 inhibited or aggravated fluoride-regulating osteoclast mode.•Stimulation of fluoride on Smad3 expression exhibited dose-dependent manner.
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Key words
Transforming growth factor beta,Transforming growth factor beta receptor1,Smad3,Osteoclast,Fluoride,RAW264.7 cells
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