Discovery of highly potent, selective, covalent inhibitors of JAK3.
Bioorganic & Medicinal Chemistry Letters(2017)
Abstract
A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads.
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Key words
JAK3,Covalent,Irreversible inhibitor
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