Lymphocyte Subset Reference Ranges In Healthy Israeli Adults

Background: Reference ranges for adult peripheral blood lymphocyte subsets have been established in a few countries. To the best of our knowledge no broad lymphocyte subset analysis of the Israeli population has been reported.Objectives: To establish reference ranges for healthy adults in Israel and to describe age and gender specific differences, if presentMethods: Lymphocyte subsets CD3, CD3/CD4, CD3/CD8, CD3/ CD16+/CD56+, CD3/TCR alpha beta, CD3/1tR gamma delta, and CD19 were examined by flow cytornetry in 326 subjects. Samples were subdivided according to age and gender.Results: Women of all ages had a significantly higher percentage and absolute counts of CD3/CD4 cells than their male counterparts. Higher CD3/CD4 cells were observed also in the older population (>50 years). CD3/CD8 and CD3-/CD16+/CD56+ were higher in males. Older males had a lower total lymphocyte percentage and CD19 cells compared to younger men. No significant gender related differences Were observed in percent and number of CD19, CD3/TCR alpha beta or CD3/TCR gamma delta at all ages.Conclusions: These reference values could be useful in further studies for assessing changes that occur in different populations in human pathology