Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.

Bioorganic & Medicinal Chemistry Letters(2017)

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摘要
Anti-arthritic effect of 11 and 13 in mouse CIA model.
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关键词
BTK,Reversible,1H-Pyrrolo[2,3-b]pyridine,Human whole blood,Kinase selectivity,Autoimmune diseases,Rheumatoid arthritis
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