Synthesis and evaluation of prodrugs of corticotropin-releasing factor-1 (CRF 1 ) receptor antagonist BMS-665053 leading to improved oral bioavailability.

Richard A Hartz,Vivekananda M Vrudhula,Vijay T Ahuja,James E Grace,Nicholas J Lodge,Joanne J Bronson,John E Macor

Bioorganic & Medicinal Chemistry Letters（2017）

引用 4|浏览15

暂无评分

摘要

A series of phosphate and ester-based prodrugs of BMS-665053 was prepared and evaluated in rat pharmacokinetic studies with the goal of improving the oral bioavailability of the parent.

查看译文

关键词

Corticotropin-releasing factor,CRF,Pyrazinone,Prodrug

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要