Distinct spatial landscapes in clear-cell renal cell carcinoma as revealed by whole transcriptome analysis

J.I. López, M.F. Hogan, B. Sutton, S.E. Church, J.C. Angulo,C.E. Nunes-Xavier

Immuno-Oncology and Technology（2024）

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摘要

•Whole transcriptome analysis reveals distinct spatial landscapes in ccRCC.•Transcriptome spatial profiling revealed high inter- and intratumor heterogeneity in ccRCC.•Spatial transcriptomics and cell type deconvolution showed differential distribution of immune cells in ccRCC tumor interior and periphery.

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关键词

digital spatial profiling,whole transcriptome,clear-cell renal cell carcinoma

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