Neuroprotective effects of N-adamantyl-4-methylthiazol-2-amine against amyloid β-induced oxidative stress in mouse hippocampus.
Brain Research Bulletin（2017）
Abstract
•KHG26693 attenuated Aβ-induced oxidative stress in the hippocampus of mice.•KHG26693 attenuated Aβ-induced TNF-α and IL-1β enhancements.•KHG26693 attenuated Aβ-induced protein oxidation and reactive oxygen species.•KHG26693 attenuated Aβ-induced MMP-2, cPLA2, and pcPLA2 expressions.•KHG26693 attenuated Aβ-induced Nrf2 and HO-1 expressions.
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Key words
Aβ,AD,cPLA2,DCF,CAT,DMSO,EDTA,GPx,GSH,HO-1,IL-1β,iNOS,MDA,MMP-2,Nrf2,ROS,SDS,SOD,TNF-α
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