Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis.
NeuroToxicology（2016）
Abstract
•Female and male DA rats were exposed to iron overload (IO) before immunization with BBH+CFA.•IO accelerated appearance of clinical signs of EAE in female rats.•IO accelerated the progression of EAE and increased mortality in male rats.•IO increased sequestration of Fe (liver, brain and spinal cord) and elevated serum ferritin in female rats.•IO induced a higher lipid peroxidation in the brain and spinal cord of male rats.
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Key words
Chronic relapsing experimental autoimmune encephalomyelitis,Gender,Iron overload,Lipid peroxidation,Brain,Spinal cord,Liver
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