Developmental exposure to PCBs alters the activation of the auditory cortex in response to GABAA antagonism

•Dams were exposed to 0 or 6mg/kg/day PCBs during gestation and lactation.•Electrical stimulation of auditory cortex slices from adult female offspring.•Flavoprotein autofluorescence measured activation of auditory cortex.•PCB-treated females had greater activation when GABA receptors were antagonized.•These data suggest that PCBs modulate synaptic transmission in the auditory cortex.