Phosphatidylinositol 3-Kinase and Protein Kinase C Signaling Pathways Are Involved in Stromal Cell-derived Factor-1α-mediated Transmigration of Stem Cells from Apical Papilla.

Xue Chen,Jing-Yi Liu,Lin Yue,George T-J Huang,Xiao-Ying Zou

Journal of Endodontics（2016）

Cited 5|Views7

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Abstract

•The mechanism involved in stromal cell–derived factor-1α (SDF-1α)–mediated migration of stem cells from apical papilla (SCAPs) was investigated.•Inhibition of the phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) pathway reduced SDF-1α–mediated migration of SCAPs.•PI3K and PKC pathways are involved in SDF-1α–stimulated focal adhesion formation.•Phosphorylation of p85 and PKC is involved in the activated SDF-1α/CXCR4 axis.

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Key words

Migration,phosphatidylinositol 3-kinase,protein kinase C,stem cells from apical papilla,stromal cell–derived factor-1α

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