Studying The Sensitivity Of Coronary Blood Flow Using Nondimensional Analysis.

Nondimensional analysis was used to develop a novel model of coronary blood flow. In addition to general hemodynamics, the model was used to study the sensitivity of the arterial flow to variations in characteristic lumped parameters. Experimental hemodynamic data obtained from four normal healthy pigs were used in the current study. The results suggest that the mean coronary arterial flow is primarily sensitive to the flow and elasticity parameters of the coronary vasculature. Other flow features were also studied, and it was shown that the sensitivities of the general flow waveforms are influenced to different extents by the perturbations of these parameters. More specifically, the flow coefficient affects the systolic inflow more than the diastolic portion; conversely, the elasticity coefficient has more impact on the diastolic period.