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NR3C1基因Bcl-1(rs41423247)多态性位点与汉族高原肺水肿相关性分析（英文）

Du Hui,Zhao Jing,Ga Qin, Liu Yuhong,Tang Feng,Yang Yingzhong,Liu Yongnian

中国高原医学与生物学杂志（2018）

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Abstract
目的探讨NR3C1基因Bcl-1多态性位点与汉族高原肺水肿(HAPE)相关关系。方法采用病例对照研究,选取HAPE患者133例及性别年龄匹配的对照组135例。采用Sequenom Mass ARRAYSNP检测技术对Bcl-1位点进行基因分型。结果 Bcl-1的基因型GG在HAPE组(69.9%)和对照组(56.3%)组间差异有显著性(P<0.05);等位基因G在HAPE组(83.5%)和对照组(74.4%)组间差异有显著性(P<0.05),odds ratio为1.732(1.134~2.645)。结论 Bcl-1的基因型GG和等位基因G在HAPE组和对照组间差异有显著性,可能与HAPE的病理生理过程相关。
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Key words
HAPE,NR3C1,SNP,Bcl-1(rs41423247)
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