PyMut: A Web Tool for Overlapping Gene Loss-of-Function Mutation Design.

IEEE/ACM Transactions on Computational Biology and Bioinformatics（2018）

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摘要

Loss-of-function study is an effective approach to research gene functions. However, currently most of such studies have ignored an important problem (in this paper, we call it “off-target” problem), that is, if the target gene is an overlapping gene (A gene whose expressible nucleotides overlaps with that of another one), loss-of-function mutation by deleting the complete open reading frame (ORF)...

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关键词

Genomics,RNA,Bioinformatics,Strain,Protein sequence,Web servers

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