A true full-duplex 32-channel 0.135cm3 neural interface.

We propose a novel neuromodulation (NM) interface with true 100mVpp linear input range that enables concurrent neural sensing and stimulation. It includes a flexible 4-driver-to-32-contact stimulator that can deliver up to 3.1mA per driver (total 12.4mA) and a 32-channel sensing unit. This 32-channel interface meets design requirements of human-quality implants at unprecedented electronic miniaturization (20x reduction) as compared to prior art. It offers major new clinical perspectives: always-on sensing for enhanced closed-loop therapy, multi-channel arbitrary stimulation waveforms with user-friendly programming, and a high spatial resolution neural interface for precise target localization.