Synthesis of 14ß-cyanomethyl derivatives of estradiol and the estimation of their antineoplastic activity in vitro
Russian Journal of Bioorganic Chemistry（2016）
Abstract
14ß-Cyanomethyl derivatives of estrone and estradiol have been synthesized starting from 3-benzoyloxyestra-1,3,5(10),14,16-pentaen-17-yl acetate. A comparative study of their cytotoxicity in breast carcinoma ZR-75-1, cervix uteri carcinoma M-HeLa, uterus leiomyosarcoma SK-UT-1B, breast adenocarcinoma MCF-7, ovary teratocarcinoma PA-1, acute myelogenous leukemia KG-1, and Burkitt’s lymphoma Raji cells has been performed.
MoreTranslated text
Key words
nitro steroids,nitriles,reductive cleavage,human tumor cell lines
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined