Development of an in vivo radionuclide generator by labeling bleomycin with Os
Journal of Radioanalytical and Nuclear Chemistry(2011)
摘要
Bleomycin (BLM) has been labeled with various radioisotopes and widely used in therapy and diagnosis. Os is a parent radionuclide with 15.4 day half-life and decays by beta emission to Ir, which is a radionuclide with 4.96 s half-life. BLM was labeled with Os-hexachloro-osmate and its distribution and stability in wild-type mice was determined. The complex was obtained at the pH 2 in normal saline at 90 °C in 48 h. Radio-TLC showed an overall radiochemical yield of 93–97%, radio-chemical purity > 97%. The biodistribution study for Os-hexachloro-osmate and Os-BLM were carried in wild type-mice up to 14 days. Lungs, liver and spleen uptake increased 24–72 h after administration of Os-BLM. 24 h after administration, the radioactivity of the kidney increased and remained constant.
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关键词
Bleomycin,191,Os,Biodistribution,Radiolabeling,Imaging
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