The phenotype control kernel of a biomolecular regulatory network

BMC Systems Biology(2018)

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摘要
Controlling complex molecular regulatory networks is getting a growing attention as it can provide a systematic way of driving any cellular state to a desired cell phenotypic state. A number of recent studies suggested various control methods, but there is still deficiency in finding out practically useful control targets that ensure convergence of any initial network state to one of attractor states corresponding to a desired cell phenotype.
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关键词
Biological network,Boolean network model,Attractor,Basin,Target control,Network control,Phenotype control kernel,Layered network,Converging tree
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