The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space
Behavioural Brain Research(2017)
摘要
•PTZ kindling impairs novelty-driven more than fear-driven exploration.•Reduced exploratory drive after kindling co-varies with poorer spatial memory.•Kindling induces hyperactivity within midbrain dopamine neurons.•Kindling blunts spatial novelty-induced activation of midbrain dopamine neurons.•Spatial detection and spatial motivation impairments may feed into each other.
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关键词
PTZ,VTA,NFT
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