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Anti-RAGE antibody attenuates isoflurane-induced cognitive dysfunction in aged rats

Chengmei Shi, Duan Yi,Zhengqian Li,Yongde Zhou,Yiyun Cao,Yan Sun,Dehua Chui,Xiangyang Guo

Behavioural Brain Research（2017）

Cited 12|Views15
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Abstract
•Isoflurane exposure induced impairment of hippocampus-dependent spatial learning and memory in aged rats.•RAGE antibody administration improve the BBB disruption, reduce the neuroinflamation and Aβ deposition.•RAGE antibody administration attenuated the cognitive impairment induced by isoflurane exposure.
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Key words
RAGE,BBB,Cognitive dysfunction,Neuroinflammation,Aβ,Isoflurane
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