Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum

•Overpressure blast injury (OBI) induces oxidative stress and inflammation in lung and brain.•Repeated OBI causes edema and disrupts blood brain barrier while single injury has no significant effect.•There is a positive correlation between blast injury induced brain edema and lung edema.•Immunoreactivity of gliosis markers like Iba-1 and GFAP increased in the cortex after OBI. Moreover NF-κB and NGF proteins also increased.•Tromboplastin activity rises in the brain tissue by repeated injury and this indicates that it is prone to bleeding after OBI.•Serum leptin levels are significantly elevated after OBI.