Behavioral characterization of the anterior injection model of subarachnoid hemorrhage

Behavioural Brain Research(2017)

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摘要
•Flex field analysis of SAH animals showed a significant reduction of locomotor activity compared to controls in correlation with severity.•SHIRPA score revealed a significant reduction in motor behavior in SAH animals two days after surgery.•SAH animals show a significant increase of GFAP expression, Fluoro Jade C and TUNEL positive cells as well as microthrombi.•Significant negative correlation between flex field righting and the number of degenerative neurons or microthrombi.
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关键词
Subarachnoid hemorrhage,Anterior injection model,Behavior,SHIRPA,Flex field
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