Maternal hypomagnesemia alters hippocampal NMDAR subunit expression and programs anxiety-like behaviour in adult offspring

R.N. Schlegel,J.G. Spiers,K.M. Moritz,C.L. Cullen,S.T. Björkman,T.M. Paravicini

Behavioural Brain Research（2017）

引用 9|浏览16

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摘要

•Maternal Mg deficiency programmed anxiety-like behaviours in adult male offspring.•Maternal Mg deficiency reduced hippocampal GluN1 and GluN2A in male offspring.•Female offspring of Mg-deficient dams had increased GluN1, GluN2A and GluN2B.•Maternal Mg deficiency increased hippocampal GluN2B:GluN2A in adult offspring.

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关键词

Magnesium deficiency,Developmental programming,Fetal programming,Hypomagnesemia,Anxiety,NMDA receptor

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