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The essential role of hippocampal alpha6 subunit-containing GABAA receptors in maternal separation stress-induced adolescent depressive behaviors

Linjie Yang,Ting Xu,Ke Zhang,Zhisheng Wei,Xuran Li,Mingfa Huang,Gregory M. Rose,Xiang Cai

Behavioural Brain Research（2016）

Cited 23|Views3
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Abstract
•Rats with MS experienced reduced Gabra6 expression and depressive behaviors.•Furosemide’s effects on eIPSCs and miniature IPSPs were occluded in rats with MS.•Knockdown of hippocampal Gabra6 expression mimicked furosemide’s effects.•Knockdown of hippocampal Gabra6 expression produced depressive behaviors.
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Key words
Hippocampus,GABAA receptor,Maternal separation stress,Depression,Synaptic transmission
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