Going down the tubes! Impact on seizure control of antiepileptic medication given via percutaneous feeding tubes

•Administering AEDs via PEG has complex interactions influencing seizure control.•Absorption site, excipients, and bioavailability significantly influence AED outcomes.•AED interaction with nutritional feed and PEG type can also determine AED efficacy.•In PWE and PEG, numerous factors affect AED delivery and are poorly researched.•This vulnerable group of PWE is best managed by a multidisciplinary team approach.