Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome

Damien Colas,Bayarsaikhan Chuluun,Craig C. Garner,H. Craig Heller

Neurobiology of Learning and Memory（2017）

引用 14|浏览12

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摘要

•Acute dose of GABAAR antagonist flumazenil enables novel object recognition in Ts65Dn mice.•Short-term chronic doses of flumazenil restores novel object recognition ability in young Ts65Dn.•Short-term chronic treatment old Ts65Dn mice restores their novel object recognition ability.

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关键词

GABA,Learning disability,Novel object recognition,Ts65Dn,Long-term memory,Neuronal plasticity

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